It has been suggested that the development of tinnitus may involve the release of chemicals that are toxic to the nervous system (neurotoxins). Therefore, it is believed that compounds which have neuroprotective and regenerative properties, may be able to reduce the severity of the condition [[i]].
Carovorine is a neuroprotective compound which has been shown to be effective in preventing damage to the cells in the inner ear when applied as an eardrop [[ii]].
However, these early studies have been conducted on animal models, so it remains to be seen whether caroverine is effective when tested on human subjects. Caroverine is currently not available in the USA.
[i] Ehrenberger K et al. Topical administration of Caroverine in somatic tinnitus treatment: proof-of-concept study. Int Tinnitus J. 2005;11(1):34-7
[ii] Chen Z et al. Pharmacokinetics of caroverine in the inner ear and its effects on cochlear function after systemic and local administrations in Guinea pigs. Audiol Neurootol. 2003 Jan-Feb;8(1):49-56
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